A clinical investigation of the efficacy of Cromosol solution (in 2% and 4% concentrations) produced by Polfa Pharmaceutical Works in Rzeszow compared with Lomusol solution produced by Fisons in the treatment of pollinosis in children and teenagers

Ryszard Kurzawa, Mieczyslaw Kossek, Zbigniew Doniec, Henryk Mazurek, Bozena Samelska, Ewa Urbanek, Urszula Jedrys

Institute for Tuberculosis and Lung Diseases, Pediatric Division in Rabka, Poland

Published in: R. Spiewak (Editor): "Pollens and Pollinosis: Current Problems". Institute of Agricultural Medicine, Lublin (Poland) 1995, pages 103-104.

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Polski Po Polsku

Objective

  1. Comparative evaluation of the efficacy of treatment of pollinosis with two different nasal solutions of sodium cromoglycate: 2% concentration of Cromosol versus Lomusol.
  2. Evaluation of purposefulness of treating pollinosis with sodium cromoglycate applied in the nose and throat and investigation of the benefits of using Cromosol in 2% and 4% concentrations.

Material

The investigation was conducted in 60 patients aged between 7 and 16, both boys and girls. All study patients had been routinely diagnosed to suffer from pollinosis and none suffered from any other disease which might have interfered with the course of treatment.

Methods

The study comprised 20 days of treatment. During this time sodium cromoglycate was administered to two even groups and four subgroups of patients in the form of applications to the nose alone or simultaneously to the nose and the throat. Nasal applications of 2% Cromosol and Lomusol were administered for 10 consecutive days each and the subgroups received the applications in the reversed order. The group of patients treated with the "nose-and-throat" method received additional applications of 4% Cromosol to the throat for 20 days of treatment. The initial state of health and all the changes were evaluated on the basis of 3 medical examinations, 3 self-evaluations and daily case records.

Results

  1. Besides nose symptoms, throat symptoms, related especially to the lymphatic tissue, were observed in all study patients.
  2. Overall health improved at the second medical examination compared to the first one and was better at the third medical examination compared to the second one.
  3. No differences in the efficacy of treatment with 2% Cromosol and Lomusol were observed.
  4. In patients treated with sodium cromoglycate applied simultaneously to the nose and throat, certain symptoms were relieved more satisfactorily and in shorter time.
  5. Minor adverse events were recorded in patients treated with both products only during the first five days of treatment.

Conclusions

  1. Pollinosis is a general allergic disease already in its beginnings and systematic treatment with sodium cromoglycate is efficacious.
  2. 2% Cromosol is as efficacious as Lomusol in treating pollinosis.
  3. Throat applications of 4% Cromosol are easy to administer and produce no serious adverse events.
  4. Treatment with sodium cromoglycate applied both to the nose and throat is purposeful in patients with pollinosis, especially when severe throat and larynx symptoms are observed.

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